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黃芩素

分析標(biāo)準(zhǔn)品,HPLC≥98%

Baicalein

CAS號：491-67-8

分子式：C15H10O5

分子量：270.24

MDL：MFCD00017459

產(chǎn)品介紹

Baicalein (5,6,7-Trihydroxyflavone) 是黃嘌呤氧化酶抑制劑，其 IC50 值為 3.12 μM。

熔點(diǎn)：256-271℃

沸點(diǎn)：575.9℃ at 760 mmHg

比旋光度：-139°(吡啶)

外觀：黃色粉末

溶解性：DMSO  :  50  mg/mL  (185.02  mM;  Need  ultrasonic)，DMSO母液分裝保存，不能反復(fù)凍融，-20℃，一個月內(nèi)使用，-80℃，半年內(nèi)使用。

敏感性：對光和熱敏感

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(141篇)

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114. [IF=4.3] Hujun Du et al."Exploring the Underlying Mechanisms of Qingxing Granules Treating H1N1 Influenza Based on Network Pharmacology and Experimental Validation."Pharmaceuticals.2024 Jun;17(6):731

113. [IF=5.2] Qiuyan Jiang et al."Baicalein ameliorates lipid accumulation in HepG2 cells via the pregnane X receptor signaling pathway."Food Bioscience".2024 Aug;60:104482

112. [IF=5.4] Dan Yang et al."Study on the Effect of Pharmaceutical Excipient PEG400 on the Pharmacokinetics of Baicalin in Cells Based on MRP2, MRP3, and BCRP Efflux Transporters."Pharmaceutics".2024 Jun;16(6):731

111. [IF=5.6] Han Yu et al."Functional Identification of HhUGT74AG11—A Key Glycosyltransferase Involved in Biosynthesis of Oleanane-Type Saponins in Hedera helix."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES".2024 Jan;25(7):4067

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109. [IF=6.6] Lingling Tang et al."Cleaner production of baicalein by novel high-temperature-little-acid hydrolysis of baicalin."Green Chemistry Letters and Reviews.10.1080/17518253.2024.2319698

108. [IF=7.9] Yanqin Luo et al."Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota."PHYTOMEDICINE".2024 May;:155706

107. [IF=5.4] Botong Li et al."Protective effect of San Huang Pill and its bioactive compounds against ulcerative colitis in Drosophila via modulation of JAK/STAT, apoptosis, Toll, and Nrf2/Keap1 pathways."JOURNAL OF ETHNOPHARMACOLOGY.2024 Mar;322:117578

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104. [IF=2.8] Qingmei Gong et al."Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer’s disease."IMMUNOBIOLOGY.2023 Nov;:152761

103. [IF=6] Zeru Xu et al."Targeted screening of baicalein inhibitor with controlling lipid and protein oxidation for quality preservation of grass carp fillets."LWT-FOOD SCIENCE AND TECHNOLOGY.2023 Nov;:115526

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100. [IF=5.1] Meiling Yu et al."Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation."CHEMICO-BIOLOGICAL INTERACTIONS.2023 Sep;382:110607

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90. [IF=6.208] Na Li et al."STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2023 Jan;24(3):2987

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82. [IF=5.195] Xiaojing Wang et al."Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice."JOURNAL OF ETHNOPHARMACOLOGY.2022 Nov;:115919

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68. [IF=4.412] Jingjing Liao et al."Heterologous Biosynthesis of Health-Promoting Baicalein in Lycopersicon esculentum."MOLECULES. 2022 Jan;27(10):3086

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65. [IF=7.514] Jinmiao Sun et al."Chitosan binding to a novel alfalfa phytoferritin nanocage loaded with baicalein: Simulated digestion and absorption evaluation."Food Chem. 2022 Aug;386:132716

64. [IF=3.41] Zhi-dan Gao et al."Mechanistic insights into the amelioration effects of lipopolysaccharide-induced acute lung injury by baicalein: An integrated systems pharmacology study and experimental validation."Pulm Pharmacol Ther. 2022 Mar;:102121

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58. [IF=3.263] Zongchun Yang et al."Baicalein improves glucose metabolism in insulin resistant HepG2 cells."Eur J Pharmacol. 2019 Jul;854:187

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48. [IF=5.875] Guangjiao You et al."Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles."Int J Pharmaceut. 2021 May;601:120546

47. [IF=3.597] Jingying Qiu et al."Assessment of a bifendate derivative bearing a 6,7-dihydro-dibenzo[c,e]azepine scaffold as a potential anti-metastatic agent."Medchemcomm. 2018 Nov;9(11):1826-1830

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